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CRYODERM’s®
Key ingredients
are clinically proven to dilate blood vessels,
inhibit inflammation, platelet adhesion, and oxidative damage
through the production
of Nitric Oxide and cGMP.
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How it Works
Research has demonstrated that the ingredients in CRYODERM stimulate nitric oxide (NO) formation through activation of Ca2+/calmodulin-dependent protein kinase (CaM kinase). Nitric oxide, in turn, binds to and activates guanylyl cyclase. This enzyme catalyzes the dephosphorylation of GTP to cyclic GMP (cGMP), which serves as a second messenger for signaling smooth muscle relaxation.
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Vascular effects of NO:
- Direct vasodilation (flow dependent and receptor mediated)
- Indirect vasodilation by inhibiting vasoconstrictor influences (e.g., inhibits angiotensin II and sympathetic vasoconstriction)
- Anti-thrombotic effect - inhibits platelet adhesion to the vascular endothelium
- Anti-inflammatory effect - inhibits leukocyte adhesion to vascular endothelium;
- Anti-proliferative effect - inhibits smooth muscle hyperplasia
- Scavenges free radicals, improving cellular health
cGMP:
Cyclic GMP induces smooth muscle relaxation by multiple mechanisms including:
- Increased intracellular cGMP, which inhibits calcium entry into the cell, and decreases intracellular calcium concentrations.
- Activates K+ channels, which leads to hyperpolarization and relaxation
- Stimulates a cGMP-dependent protein kinase that activates myosin light chain phosphatase, the enzyme that dephosphorylates myosin light chains, which leads to smooth muscle relaxation.
- Induces smooth muscle relaxation
- Inhibits blood clotting (platelet adhesion).
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References:
http://www.cvphysiology.com/Blood%20Flow/BF011.htm
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